Influence of Co-Excipients on Release Rate of Aceclofenac from Carbopol Controlled Release Matrix Tablets

Riyaz Shaikh*, Gaffar Sayyad,  Yogesh Bafana , Harish Lukkad

Abstract
Objective: To develop matrix tablets for controlled release of aceclofenac and to study the effect of various co-exipients on release of drug.
Methods: Matrix tablets of aceclofenac were prepared by using polymer like carbopol 974P and different co-excipients with varying proportions, by direct compression method. The enfluence of different proportion of microcrystalline cellulose (MCC), lactose and dibasic calcium phosphate (DCP) on the release rate of aceclofenac from matrix tablet was studied. The tablets were subjected to physicochemical studies, in vitro drug release carried out in phosphate buffer at pH 7.4. The drug release kinetics from the tablet was studied using PCP-Disso software.
Results:Microcrystalline cellulose formulation with T 90 of 5.70 hrs,5.62 hrs and 7.20 hrs from formulation F1,F2,and F3 respectively showed increased the release rate of drug followed by lactose formulation with dissolution T 90 of 6.40 hrs,7.56 hrs and 6.77 hrs from F4,F5,and F6 respectively. And with DCP formulation showed much slower in rate release of drug from carbopol matrix tablet with dissolutionT 90 of 7.90 hrs, 7.82 hrs and 7.65 hrs from F7, F8 and F9 respectively.
Conclusion: The results of the study revealed that release rate of drug were increased by MCC and lactose while decreased by DCP.

Key words: Aceclofenac, Carbopol 974P, Matrix tablets, Co-excipients