Formulation and Evaluation of Oral Floatable In-Situ Gel of Diltiazem HCl

pratibha panwar, Deepak Chourasiya, Gaurav jain, R V Sheorey

Abstract
ABSTRACT
Objective: The present investigation deals with the formulation, optimization and evaluation of sodium alginate and HPMC based floating oral In situ gel of Diltiazem Hydrochloride. Sodium alginate and HPMC used as a polymer and CaCO3 was used as a cross-linking agent. In-situ forming polymeric formulation drug delivery systems is in sol form before administration in the body, but once administered, undergoes gelation in-situ to form a gel. The formulation of gel depends upon factors like temperature modulation, pH changes, presence of ions and ultraviolet irradiation from which drug gets released in sustained and controlled manner. The present investigation deals with the formulation, optimization and evaluation of sodium alginate and HPMC based floating oral In situ gel of Diltiazem Hydrochloride.
Methods: The objective of this study was to develop a novel in- situ gel system for sustained drug delivery using natural biodegradable polymers. The system utilizes polymers that exhibit sol-to-gel phase transition due to change in specific physicochemical parameters.
Results and conclusion: In-situ gel was formed at a biological pH from designed set of experiments, it was evident that formulation containing 2.5% of sodium alginate control the release of drug for longer duration. Water uptake by F-5 batch at 1.5 hr. is 10.059 % and it is having maximum water uptake capacity. The in-situ gel exhibited the expected, viscosity, drug content, pH, in vitro gelling capacity, in vitro floating ability, water uptake ability and sustained drug release.

Key words: Key Words: Oral, In-situ gel, sodium alginate, HPMC, Diltiazem HCl.