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Klinik Psikofarmakoloji Bülteni
Bulletin of Clinical Psychopharmacology
Periodical of Psikofarmakoloji Derneği
Journal Home Page		ISSN: 1017-7833 (Print)
ISSN: 1302-9657 (Online)
Language: [ Turkish ]   [ English ]  

  » Volume 23, Issue 1
      pp. 1-128

 

Open Access

Original Research



The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder

Mehmet Yumru, Esen Savaş, H. Serdar Gergerlioğlu, Kemal Başaralı, Aysun Kalenderoğlu, Haluk A. Savaş, Sadık Büyükbaş.

A B S T R A C T 

Abstract
Objective: In this study we aimed to evaluate the relationship between serum
leptin levels, metabolic syndrome and treatment in bipolar patients.



Method: Sixty bipolar I disorder (BD) patients were enrolled; 29 patients were on mood
stabilizer (MS) (lithium, valproic acid, carbamazepin, and lamotrigine)
treatment, 31 patients were on atypical antipsychotics (AA) (risperidone,
quetiapine, and olanzapine) for at least 3 months . Metabolic syndrome (MetS)
was evaluated according to NCEP ATP III (Adult Treatment Protocol of the
National Cholesterol Education Programme) criteria.



Results: 36.7% of the
patients were recognized as MetS. The AA subgroup had significantly more MetS
than MS. Abdominal obesity was significantly correlated with leptin levels in BD.
No significant association was found between MetS and leptin levels in BD.



Discussion: AA taking bipolar patients had higher MetS rates. However, there was
no significant difference among AAs for inducing MetS. Leptin levels were
significantly correlated with abdominal obesity in bipolar patients but seem not
to be associated with MetS.

Key words: Bipolar disorder, metabolic syndrome, leptin, atypical antipsychotics


İkiuçlu Bozuklukta Metabolik Sendrom, Serum Leptin Düzeyleri ve Tedavi İlişkisi

Özet
Amaç: Bu çalışmada ikiuçlu bozuklukta metabolik sendrom, serum leptin seviyeleri
ve tedavi arasındaki ilişkinin değerlendirilmesi amaçlanmıştır.



Yöntem: En az 3 ay süre ile atipik antipsikotik (AA) (risperidon, ketiapin,
olanzapin) almış 31 ve duygudurum düzenleyici (DD) (lityum, valproik asit,
karbamazepin, lamotrijin) almış 29 hasta olmak üzere ikiuçlu bozukluk I tanısı
konan ötimik dönemdeki toplam 60 hasta çalışmaya alındı. Metabolik Sendrom (MetS)
NCEP ATP III (Adult Treatment Protocol of the National Cholesterol Education
Program) ölçütlerine göre tarandı.



Bulgular: Hastaların %36.7?sinde MetS görüldü. AA alt grubunda DD alt grubuna
oranla daha yüksek oranda MetS görüldü. Abdominal obesite ikiuçlu bozuklukta
leptin seviyeleri ile anlamlı düzeyde ilişkili olarak saptandı. İkiuçlu
bozuklukta leptin seviyeleri ve MetS arasında anlamlı bir ilişki bulunamadı.



Tartışma: AA kullanan ikiuçlu hastalar yüksek MetS oranlarına sahipti. Bununla
birlikte AA?ler arasında MetS sıklı

Anahtar Kelimeler: İkiuçlu bozukluk, metabolik sendrom, leptin, atipik antipsikotikler


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How to Cite this Article
Pubmed Style

Yumru M, Savaş E, Gergerlioğlu HS, Başaralı K, Kalenderoğlu A, Savaş HA, Büyükbaş S. [The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder ]. BCP. 2008; 18(2): 79-83. .


Web Style

Yumru M, Savaş E, Gergerlioğlu HS, Başaralı K, Kalenderoğlu A, Savaş HA, Büyükbaş S. [The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder ]. www.scopemed.org/?mno=2987 [Access: May 22, 2013]. .


AMA (American Medical Association) Style

Yumru M, Savaş E, Gergerlioğlu HS, Başaralı K, Kalenderoğlu A, Savaş HA, Büyükbaş S. [The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder ]. BCP. 2008; 18(2): 79-83. .


Vancouver/ICMJE Style

Yumru M, Savaş E, Gergerlioğlu HS, Başaralı K, Kalenderoğlu A, Savaş HA, Büyükbaş S. [The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder ]. BCP. (2008), [cited May 22, 2013]; 18(2): 79-83. .


Harvard Style

Yumru, M., Savaş, E., Gergerlioğlu, H. S., Başaralı, K., Kalenderoğlu, A., Savaş, H. A. & Büyükbaş, S. (2008) [The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder ]. BCP, 18 (2), 79-83. .


Turabian Style

Yumru, Mehmet, Esen Savaş, H. Serdar Gergerlioğlu, Kemal Başaralı, Aysun Kalenderoğlu, Haluk A. Savaş, and Sadık Büyükbaş. 2008. [The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder ]. Bulletin of Clinical Psychopharmacology, 18 (2), 79-83. .


Chicago Style

Yumru, Mehmet, Esen Savaş, H. Serdar Gergerlioğlu, Kemal Başaralı, Aysun Kalenderoğlu, Haluk A. Savaş, and Sadık Büyükbaş. "[The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder ]." Bulletin of Clinical Psychopharmacology 18 (2008), 79-83. .


MLA (The Modern Language Association) Style

Yumru, Mehmet, Esen Savaş, H. Serdar Gergerlioğlu, Kemal Başaralı, Aysun Kalenderoğlu, Haluk A. Savaş, and Sadık Büyükbaş. "[The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder ]." Bulletin of Clinical Psychopharmacology 18.2 (2008), 79-83. Print..


APA (American Psychological Association) Style

Yumru, M., Savaş, E., Gergerlioğlu, H. S., Başaralı, K., Kalenderoğlu, A., Savaş, H. A. & Büyükbaş, S. (2008) [The relationship of metabolic syndrome, serum leptin levels and treatment in bipolar disorder ]. Bulletin of Clinical Psychopharmacology, 18 (2), 79-83. .


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