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Medical Archives
Periodical of AVICENA, d.o.o., Sarajevo
Journal Home Page		ISSN: 0350-199X (Print)
ISSN: 1986-5961 (Online)
Language: [ English ]  

  » Volume 67, Issue 2
      pp. 84-151
  » Volume 67, Issue 1
      pp. 4-78

 

Open Access

Original Research



The Incidence of ANA and ETI-dsDNA Detected by Enzyme Immunoassays and Indirect Immunofluorescence Assay (IFA)

Izeta Aganovic-Musinovic, Lamija Prljaca-Zecevic, Djemo Subasic.

A B S T R A C T 

Abstract
While the SL E (Systemic Lupus Erythematosus) specificity of ANA is low, that of anti-dsDNA autoantibodies is high. The DNA used in the assay must be double stranded: autoantibodies to single –stranded (ss) DNA exist in many diseases and specific to none. The prevalence (70%) of antidsDNA autoantibodies is much higher in SL E, giving a higher diagnostic sensitivity than the similarly disease-specific anti-Sm autoantibodies (30%). Anti-dsDNA autoantibodies are usually detected by very analytically sensitive techniques, such as ELISA (Enzyme Linked Immunosorbent Assay). Within SLE, ds-DNA autoantibodies tend to associate with the presence of glomerulonephritis. Their levels are used to monitor disease activity. We suggest the use of ds-DNA to find the difference between SL E patients with benign variants and classical syndrome of severe skin and renal disease.

Key words: SLE , systemic lupus erythematosus, ANA, anti-nuclear antibodies, ds-DNA, doublestranded DNA antibodies, IFA, immunoflourescence assay, ELISA , enzyme linked immunosorbent assay


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How to Cite this Article
Pubmed Style

Aganovic-Musinovic I, Prljaca-Zecevic L, Subasic D. The Incidence of ANA and ETI-dsDNA Detected by Enzyme Immunoassays and Indirect Immunofluorescence Assay (IFA) . Med Arh. 2010; 64(2): 68-70.


Web Style

Aganovic-Musinovic I, Prljaca-Zecevic L, Subasic D. The Incidence of ANA and ETI-dsDNA Detected by Enzyme Immunoassays and Indirect Immunofluorescence Assay (IFA) . www.scopemed.org/?mno=3695 [Access: May 18, 2013].


AMA (American Medical Association) Style

Aganovic-Musinovic I, Prljaca-Zecevic L, Subasic D. The Incidence of ANA and ETI-dsDNA Detected by Enzyme Immunoassays and Indirect Immunofluorescence Assay (IFA) . Med Arh. 2010; 64(2): 68-70.


Vancouver/ICMJE Style

Aganovic-Musinovic I, Prljaca-Zecevic L, Subasic D. The Incidence of ANA and ETI-dsDNA Detected by Enzyme Immunoassays and Indirect Immunofluorescence Assay (IFA) . Med Arh. (2010), [cited May 18, 2013]; 64(2): 68-70.


Harvard Style

Aganovic-Musinovic, I., Prljaca-Zecevic, L. & Subasic, D. (2010) The Incidence of ANA and ETI-dsDNA Detected by Enzyme Immunoassays and Indirect Immunofluorescence Assay (IFA) . Med Arh, 64 (2), 68-70.


Turabian Style

Aganovic-Musinovic, Izeta, Lamija Prljaca-Zecevic, and Djemo Subasic. 2010. The Incidence of ANA and ETI-dsDNA Detected by Enzyme Immunoassays and Indirect Immunofluorescence Assay (IFA) . Medical Archives, 64 (2), 68-70.


Chicago Style

Aganovic-Musinovic, Izeta, Lamija Prljaca-Zecevic, and Djemo Subasic. "The Incidence of ANA and ETI-dsDNA Detected by Enzyme Immunoassays and Indirect Immunofluorescence Assay (IFA) ." Medical Archives 64 (2010), 68-70.


MLA (The Modern Language Association) Style

Aganovic-Musinovic, Izeta, Lamija Prljaca-Zecevic, and Djemo Subasic. "The Incidence of ANA and ETI-dsDNA Detected by Enzyme Immunoassays and Indirect Immunofluorescence Assay (IFA) ." Medical Archives 64.2 (2010), 68-70. Print.


APA (American Psychological Association) Style

Aganovic-Musinovic, I., Prljaca-Zecevic, L. & Subasic, D. (2010) The Incidence of ANA and ETI-dsDNA Detected by Enzyme Immunoassays and Indirect Immunofluorescence Assay (IFA) . Medical Archives, 64 (2), 68-70.


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