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Generalized tonic-clonic seizure induced by the extended- release bupropion hydrochloride formulation Erhan Dedeoğlu, Başak Bayram, Ali Ufuk Kızıler, Berrin Dedeoğlu.
| A B S T R A C T | | Abstract
Bupropion hydrochloride is currently available in three formulations: immediate-release (IR), sustained-release (SR), and extended-release (ER) Bupropion Hydrochloride (HCI). It is reported that Bupropion Hcl triggers seizure activity in immediate-release and sustained- release formulations. However, such an effect has been rarely cited in the medical literature for the extended release formulation. We determined in our emergency department a 37 years old woman who was taking extended-release bupropion hydrochloride tablets and having a generalized tonic-seizure attack.While the other reasons have been researched during the evaluations of the patients Who have not had epilepsy diagnosis beforehand and have referred to the hospital at first seizure,the examinations of antidepressant drugs have to be necessary. Key words: Bupropion, Seizure, Emergency department
Bupropion HCl yavaş salınımlı formuna bağlı jeneralize tonik klonik nöbet Özet
Bupropion Hidroklorid (HCI), hızlı salınımlı , sürekli salınımlı ve yavaş salınımlı olmak üzere üç farklı formu bulunmaktadır. Bupropion HCI sürekli ve hızlı salınımlı formlarda özellikle nöbet tetiklediği bildirilmiştir. Fakat yavaş salınımlı formunun nöbet tetiklediği literatürde oldukça nadir olarak bildirilmiştir(1). Bizde vakamızda nadir olması nedeni ile, Bupropionun yavaş salınımlıformunu kullanan ve acil servise jeneralize tonik klonik nöbetle gelen 37 yaşındaki bayan hastayı vurgulamayı amaçladık.Daha önce epilepsi tanısı olmayan ve ilk nöbetle hastaneye başvuran hastaların değerlendirilmesi sırasında diğer nedenler araştırılırken, antidepressan ilaçların da sorgulanması gerekmektedir. Anahtar Kelimeler: Bupropion, Nöbet, Acil servis
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| How to Cite this Article | | Pubmed Style Dedeoğlu E, Bayram B, Kızıler AU, Dedeoğlu B. [Generalized tonic-clonic seizure induced by the extended- release bupropion hydrochloride formulation]. BCP. 2011; 21(4): 362-363. Turkish. doi:10.5455/bcp.20111001111239
Web StyleDedeoğlu E, Bayram B, Kızıler AU, Dedeoğlu B. [Generalized tonic-clonic seizure induced by the extended- release bupropion hydrochloride formulation]. www.scopemed.org/?mno=4624 [Access: May 23, 2013]. Turkish. doi:10.5455/bcp.20111001111239
AMA (American Medical Association) StyleDedeoğlu E, Bayram B, Kızıler AU, Dedeoğlu B. [Generalized tonic-clonic seizure induced by the extended- release bupropion hydrochloride formulation]. BCP. 2011; 21(4): 362-363. Turkish. doi:10.5455/bcp.20111001111239
Vancouver/ICMJE StyleDedeoğlu E, Bayram B, Kızıler AU, Dedeoğlu B. [Generalized tonic-clonic seizure induced by the extended- release bupropion hydrochloride formulation]. BCP. (2011), [cited May 23, 2013]; 21(4): 362-363. Turkish. doi:10.5455/bcp.20111001111239
Harvard StyleDedeoğlu, E., Bayram, B., Kızıler, A. U. & Dedeoğlu, B. (2011) [Generalized tonic-clonic seizure induced by the extended- release bupropion hydrochloride formulation]. BCP, 21 (4), 362-363. Turkish. doi:10.5455/bcp.20111001111239
Turabian StyleDedeoğlu, Erhan, Başak Bayram, Ali Ufuk Kızıler, and Berrin Dedeoğlu. 2011. [Generalized tonic-clonic seizure induced by the extended- release bupropion hydrochloride formulation]. Bulletin of Clinical Psychopharmacology, 21 (4), 362-363. Turkish. doi:10.5455/bcp.20111001111239
Chicago StyleDedeoğlu, Erhan, Başak Bayram, Ali Ufuk Kızıler, and Berrin Dedeoğlu. "[Generalized tonic-clonic seizure induced by the extended- release bupropion hydrochloride formulation]." Bulletin of Clinical Psychopharmacology 21 (2011), 362-363. Turkish. doi:10.5455/bcp.20111001111239
MLA (The Modern Language Association) StyleDedeoğlu, Erhan, Başak Bayram, Ali Ufuk Kızıler, and Berrin Dedeoğlu. "[Generalized tonic-clonic seizure induced by the extended- release bupropion hydrochloride formulation]." Bulletin of Clinical Psychopharmacology 21.4 (2011), 362-363. Print.Turkish. doi:10.5455/bcp.20111001111239
APA (American Psychological Association) StyleDedeoğlu, E., Bayram, B., Kızıler, A. U. & Dedeoğlu, B. (2011) [Generalized tonic-clonic seizure induced by the extended- release bupropion hydrochloride formulation]. Bulletin of Clinical Psychopharmacology, 21 (4), 362-363. Turkish. doi:10.5455/bcp.20111001111239
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