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Gülhane Tıp Dergisi
Gulhane Medical Journal
Periodical of Gulhane Military Medical Faculty
Journal Home Page		ISSN: 1302-0471 (Print)
ISSN: 2146-8052 (Online)
Language: [ Turkish ]   [ English ]  

  » Volume 55, Issue 1
      pp. 1-75

 

Open Access

Original Research



MIB-1, Her2/neu or CD34 useful prognostic factors in stage II and III testicular non-seminomatous germ cell tumors?

Selmin Ataergin1, Ahmet Özet1, Fikret Arpacı1, Selim Kılıç2, Önder Öngürü3, Melih Alömeroğlu3, Ömer Günhan3.

A B S T R A C T 

Abstract
In this study we analyzed immunocytochemical expression of MIB-1, HER2/neu and CD34 in stage II and III testicular non-seminomatous germ cell tumors to investigate if these factors may be useful in determining the prognosis of the disease. Orchiectomy specimens of 64 patients were studied for MIB-1, HER2/neu and CD34 immunostaining. In 47% and 30% of the cases MIB-1 immunostaining level was under the median value in patients with stage II and III disease, respectively. The intensity of immunostaining with CD34 was (+) in 31% of the cases, (++) in 40% of the cases and (+++) in 29% of the cases in stage II tumors. The intensity of CD34 immunostaining was (++) in 26% and (+++) in 73% of the patients with stage III tumors. None of the specimens were stained with HER2/neu. The intensity of CD34 and MIB-1 immunostaining increased with advancing stage. This study revealed that MIB-1, CD34 or HER2/neu immunostaining are not good prognostic factors to predict the survival in patients with stage II and III testicular non-seminomatous germ cell tumors.

Key words: CD34, HER2/neu, MIB-1, non-seminomatous, testicular germ cell tumor


MIB-1, Her2/neu veya CD34 testisin evre II ve III non-seminomatöz germ hücreli tümörlerinde kullanışlı prognostik faktörler midir?

Özet
Bu çalışmada MIB-1, HER2/neu ve CD34 immünhistokimyasal ekspresyonunun testisin evre II ve III non-seminomatöz germ hücreli tümörlerinde ekspresyonuna bakarak, bu faktörlerin hastalığın prognozunu belirlemede yardımcı olup olamayacağını araştırdık. Altmış dört hastaya ait orşiektomi örnekleri MIB-1, HER2/neu ve CD34 immün boyanma ile incelendi. Olguların sırasıyla %47 ve %30'unda immün boyanma düzeyi evre II ve III olgularda medyan değerin altında bulundu. CD34 ile immün boyanma yoğunluğu evre II olguların %31'inde (+), %40'ında (++) ve %29'unda (+++) olarak bulundu. CD34 immün boyanma yoğunluğu evre III olguların %26'sında (++) ve %73'ünde (+++) olarak bulundu. Örneklerin hiçbirisi HER2/neu ile boyanma göstermedi. CD34 ve MIB-1 immün boyanma yoğunluğu ilerleyen evreyle birlikte artış göstermiştir. Bu çalışma MIB-1, CD34 veya HER2/neu immün boyanmasının evre II ve III testis non-seminomatöz germ hücreli tümör olgularında sağkalımı göstermede iyi birer prognostik faktör olmadığını göstermiştir.

Anahtar Kelimeler: CD34, HER2/neu, MIB-1, non-seminomatöz, testis germ hücreli tümör


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How to Cite this Article
Pubmed Style

Ataergin1 S, Özet1 A, Arpacı1 F, Kılıç2 S, Öngürü3 Ö, Alömeroğlu3 M, Günhan3 Ö. MIB-1, Her2/neu or CD34 useful prognostic factors in stage II and III testicular non-seminomatous germ cell tumors?. Gulhane Med J. 2008; 50(3): 196-200.


Web Style

Ataergin1 S, Özet1 A, Arpacı1 F, Kılıç2 S, Öngürü3 Ö, Alömeroğlu3 M, Günhan3 Ö. MIB-1, Her2/neu or CD34 useful prognostic factors in stage II and III testicular non-seminomatous germ cell tumors?. www.scopemed.org/?mno=5436 [Access: May 20, 2013].


AMA (American Medical Association) Style

Ataergin1 S, Özet1 A, Arpacı1 F, Kılıç2 S, Öngürü3 Ö, Alömeroğlu3 M, Günhan3 Ö. MIB-1, Her2/neu or CD34 useful prognostic factors in stage II and III testicular non-seminomatous germ cell tumors?. Gulhane Med J. 2008; 50(3): 196-200.


Vancouver/ICMJE Style

Ataergin1 S, Özet1 A, Arpacı1 F, Kılıç2 S, Öngürü3 Ö, Alömeroğlu3 M, Günhan3 Ö. MIB-1, Her2/neu or CD34 useful prognostic factors in stage II and III testicular non-seminomatous germ cell tumors?. Gulhane Med J. (2008), [cited May 20, 2013]; 50(3): 196-200.


Harvard Style

Ataergin1, S., Özet1, A., Arpacı1, F., Kılıç2, S., Öngürü3, Ö., Alömeroğlu3, M. & Günhan3, Ö. (2008) MIB-1, Her2/neu or CD34 useful prognostic factors in stage II and III testicular non-seminomatous germ cell tumors?. Gulhane Med J, 50 (3), 196-200.


Turabian Style

Ataergin1, Selmin, Ahmet Özet1, Fikret Arpacı1, Selim Kılıç2, Önder Öngürü3, Melih Alömeroğlu3, and Ömer Günhan3. 2008. MIB-1, Her2/neu or CD34 useful prognostic factors in stage II and III testicular non-seminomatous germ cell tumors?. Gulhane Medical Journal, 50 (3), 196-200.


Chicago Style

Ataergin1, Selmin, Ahmet Özet1, Fikret Arpacı1, Selim Kılıç2, Önder Öngürü3, Melih Alömeroğlu3, and Ömer Günhan3. "MIB-1, Her2/neu or CD34 useful prognostic factors in stage II and III testicular non-seminomatous germ cell tumors?." Gulhane Medical Journal 50 (2008), 196-200.


MLA (The Modern Language Association) Style

Ataergin1, Selmin, Ahmet Özet1, Fikret Arpacı1, Selim Kılıç2, Önder Öngürü3, Melih Alömeroğlu3, and Ömer Günhan3. "MIB-1, Her2/neu or CD34 useful prognostic factors in stage II and III testicular non-seminomatous germ cell tumors?." Gulhane Medical Journal 50.3 (2008), 196-200. Print.


APA (American Psychological Association) Style

Ataergin1, S., Özet1, A., Arpacı1, F., Kılıç2, S., Öngürü3, Ö., Alömeroğlu3, M. & Günhan3, Ö. (2008) MIB-1, Her2/neu or CD34 useful prognostic factors in stage II and III testicular non-seminomatous germ cell tumors?. Gulhane Medical Journal, 50 (3), 196-200.


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