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Asian Journal of Pharmaceutical and Biological Research
Periodical of Young Pharmaceutical and Biological Scientist Group
Journal Home Page		ISSN: 2231-2218 (Online)
Language: [ English ]  

  » Volume 2, Issue 4
      pp. 198-261
  » Volume 2, Issue 3
      pp. 161-197
  » Volume 2, Issue 2
      pp. 94-160
  » Volume 2, Issue 1
      pp. 1-93

 

Open Access

Original Research



Effect of Trichloroethylene (TCE) on Oxidative Stress and Vital Organ Damage in BALB/c Mice

Marimuthu Mathan Kumar, Siddik Uzzaman, Chandrasekharan Guruvayoorappan, Viswanathan Mariammal berlin grace.

A B S T R A C T 

Abstract
Objective: In the present study we had analyzed the effect of TCE mixture (TCE,250mg/Kg and Trichloroacetic acid (TCA) 250mg/kg) on the immune status as well asits effect on the antioxidant status in experimental animals.Methods: Several antioxidant stress like SOD, GSH and LPO, toxic effects by SGOT,SGPT and creatinine, urea level was measured. Histopathology was examined by
microscopy.
Results: It was found increased serum levels of urea, creatinine, SGOT and SGPTindicating its toxic effects on vital organs like kidney and liver. Significant decrease insuperoxide dismutase (SOD) and glutathione and increased lipid peroxide wasobserved after TCE administration in experimental animals.
Conclusion: In conclusion our present study reveals that TCE administration couldresult in immunosuppression accompanied with reduced antioxidant status

Key words: Trichloroethylene; TCA; TCE toxicity; free radical; tissue damage.


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How to Cite this Article
Pubmed Style

Kumar MM, Uzzaman S, Guruvayoorappan C, grace VMb. Effect of Trichloroethylene (TCE) on Oxidative Stress and Vital Organ Damage in BALB/c Mice. Asian J Phar Biol Res. 2011; 1(3): 240-249.


Web Style

Kumar MM, Uzzaman S, Guruvayoorappan C, grace VMb. Effect of Trichloroethylene (TCE) on Oxidative Stress and Vital Organ Damage in BALB/c Mice. www.scopemed.org/?mno=9351 [Access: May 18, 2013].


AMA (American Medical Association) Style

Kumar MM, Uzzaman S, Guruvayoorappan C, grace VMb. Effect of Trichloroethylene (TCE) on Oxidative Stress and Vital Organ Damage in BALB/c Mice. Asian J Phar Biol Res. 2011; 1(3): 240-249.


Vancouver/ICMJE Style

Kumar MM, Uzzaman S, Guruvayoorappan C, grace VMb. Effect of Trichloroethylene (TCE) on Oxidative Stress and Vital Organ Damage in BALB/c Mice. Asian J Phar Biol Res. (2011), [cited May 18, 2013]; 1(3): 240-249.


Harvard Style

Kumar, M. M., Uzzaman, S., Guruvayoorappan, C. & grace, V. M. b. (2011) Effect of Trichloroethylene (TCE) on Oxidative Stress and Vital Organ Damage in BALB/c Mice. Asian J Phar Biol Res, 1 (3), 240-249.


Turabian Style

Kumar, Marimuthu Mathan, Siddik Uzzaman, Chandrasekharan Guruvayoorappan, and Viswanathan Mariammal berlin grace. 2011. Effect of Trichloroethylene (TCE) on Oxidative Stress and Vital Organ Damage in BALB/c Mice. Asian Journal of Pharmaceutical and Biological Research, 1 (3), 240-249.


Chicago Style

Kumar, Marimuthu Mathan, Siddik Uzzaman, Chandrasekharan Guruvayoorappan, and Viswanathan Mariammal berlin grace. "Effect of Trichloroethylene (TCE) on Oxidative Stress and Vital Organ Damage in BALB/c Mice." Asian Journal of Pharmaceutical and Biological Research 1 (2011), 240-249.


MLA (The Modern Language Association) Style

Kumar, Marimuthu Mathan, Siddik Uzzaman, Chandrasekharan Guruvayoorappan, and Viswanathan Mariammal berlin grace. "Effect of Trichloroethylene (TCE) on Oxidative Stress and Vital Organ Damage in BALB/c Mice." Asian Journal of Pharmaceutical and Biological Research 1.3 (2011), 240-249. Print.


APA (American Psychological Association) Style

Kumar, M. M., Uzzaman, S., Guruvayoorappan, C. & grace, V. M. b. (2011) Effect of Trichloroethylene (TCE) on Oxidative Stress and Vital Organ Damage in BALB/c Mice. Asian Journal of Pharmaceutical and Biological Research, 1 (3), 240-249.


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